American journal of translational research
Tenecteplase combined with nicergoline improves neurological, endothelial function and short-term prognosis in AACI patients
By Gao X, Guo Y and Guo Q.
Abstract
Objective
To explore the efficacy of tenecteplase combined with nicergoline in acute atherosclerotic cerebral infarction (AACI), and screen risk indicators for poor prognosis.
Methods
A total of 368 AACI patients were enrolled and randomly allocated into a training set (n=258) and a validation set (n=110) at a 7:3 ratio. Each set was subdivided into control group (tenecteplase thrombolysis + basic treatment) and combination group (additional oral nicergoline for 14 days). National Institutes of Health Stroke Scale (NIHSS), Barthel Index (BI), serum nitric oxide (NO), and endothelin-1 (ET-1) were measured before and after treatment. Patients were followed up for 3 months to record mRS, prognosis and adverse events. Independent risk factors were screened by multivariate logistic regression, a nomogram was constructed, and its predictive efficiency was evaluated by receiver operating characteristic (ROC) curve analysis.