Frontiers in microbiology
Clinical factors associated with carbapenem resistance and in-hospital mortality in Klebsiella pneumoniae bloodstream infection: a 7-year retrospective cohort study
By Xu N, Liang Y, Zhu W and 3 others.
Abstract
Background
Carbapenem-resistant Klebsiella pneumoniae bloodstream infection (CRKP BSI) is associated with substantial mortality and limited therapeutic options, yet institutional epidemiology and risk profiles vary. We evaluated antimicrobial susceptibility, non-blood-site detection, factors associated with carbapenem resistance, and in-hospital all-cause mortality among patients with K. pneumoniae BSI at a secondary-care hospital over seven years.
Methods
We retrospectively analyzed 141 adults with K. pneumoniae BSI hospitalized at Shidong Hospital, Shanghai, China, from January 2019 through December 2025, including 49 patients with CRKP BSI and 92 with carbapenem-susceptible K. pneumoniae BSI (CSKP BSI). Clinical and microbiological data were analyzed using univariable comparisons and multivariable logistic regression.