Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
The vitality infant algorithm: A validated tool to classify food allergy outcomes in research studies
By Odoi A, Koplin JJ, Soriano VX and 10 others.
Abstract
Background
Food allergy algorithms provide a systematic approach to assigning food allergy outcomes in research studies when oral food challenges (OFC) are not performed. Currently no such algorithms validated for infants exist. We aimed to develop and validate a research algorithm for classifying infant food allergies.
Methods
An algorithm incorporating skin prick test (SPT), allergen ingestion, and reaction data was developed and validated by comparing peanut, cashew, egg, and cow's milk algorithm outcomes to OFC outcomes in infants from the Vitality (n = 285) (NCT02112734), EarlyNuts (n = 111) (ACTRN12618001990213), and HealthNuts (n = 191) studies.