La Clinica terapeutica
From Dysbiosis to Malignancy: The Female Genital Tract Microbiome in Endometrial Cancer; Insights from a Systematic Review and Meta-Analysis
By Selim AMF, Ibrahim MMLG, Elbrolosy MSM and 12 others.
Abstract
Background/aim
Emerging evidence suggests that alterations in the female genital tract microbiome may be associated with the development and progression of endometrial cancer (EC). Microbial dysbiosis may contribute to chronic inflammation, immune dysregulation, and metabolic disturbances within the endometrial microenvironment. This systematic review and meta-analysis aimed to evaluate alterations in the female genital tract microbiome in women with EC and to identify microbial patterns associated with benign, premalignant, and malignant endometrial conditions.
Methods
A systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and Meta-analysis of Observational Studies in Epidemiology (MOOSE) recommendations. Ten eligible observational studies published between 2016 and 2026 were included, comprising 775 women: 329 with benign conditions, 121 with endometrial hyperplasia, and 325 with EC. Demographic, histopathological, anatomical sampling, and microbiological data were extracted and analyzed using Review Manager, SPSS version 23, and EPI-INFO. Risk of bias was assessed using the Cochrane Collaboration tool.