Cancer medicine
Pre-Existing and Post-Cancer Major Cardiovascular Disease and Their Association With Mortality Outcomes Among Cancer Survivors in Australia
By Rahman MM, Bell K, Joshy G and 9 others.
Abstract
Background
As cancer survival improves, cardiovascular disease (CVD) has emerged as a major competing cause of death. However, population-level evidence on the burden of pre-existing and post-cancer CVD remains limited. This study aims to quantify pre-existing and post-cancer newly documented major CVD and their association with mortality outcomes among people with cancer.
Methods
Major CVD was identified using linked hospital records among 344,336 adults registered with primary invasive cancer in the New South Wales Cancer Registry from 2006 to 2016. The cohort was followed up until 31 December 2021. Fine-Grey modelling estimated sub-distributional hazard ratios (sHR) for cancer and cardiovascular mortality, and Cox proportional hazard modelling estimated hazard ratio for mortality from any cause across 20 common cancers.