Avicenna journal of phytomedicine
The effect of curcumin-piperine supplementation on liver transient elastography and biochemical indices in patients with non-alcoholic fatty liver disease: A randomized controlled trial
By Rafiee S, Bagherniya M, Khoram Z and 5 others.
Abstract
Objective
Non-alcoholic fatty liver disease (NAFLD), characterized by an excessive buildup of triglycerides in hepatocytes, currently lacks an approved pharmacological treatment. This study investigated the therapeutic potential of a curcumin-piperine supplement, leveraging curcumin's established antioxidant, anti-inflammatory, anti-steatotic, and anti-fibrotic properties, with piperine enhancing its bioavailability. The objective was to assess its impact on cardiometabolic markers, liver function, and the progression of hepatic steatosis and fibrosis.
Materials and methods
Sixty NAFLD patients were enrolled in a randomized, 12-week, placebo-controlled study. Participants were randomly assigned to a treatment group receiving a daily oral supplement of 500 mg curcumin and 5 mg piperine, or a control group receiving a placebo. Measurements of anthropometrics, biochemical indices, and hepatic steatosis and fibrosis via FibroScan were taken at baseline and study end.