EJNMMI reports
Effect of data-driven gating on the quantification of prostate cancer metastases in 68Ga-PSMA- and ¹⁸F-DCFPyL-PSMA PET/CT
By Farag A, Felder C, Hussey D and 4 others.
Abstract
Background
PSMA PET/CT using 18F‑DCFPyL and 68Ga‑labelled tracers is central to prostate cancer staging, but 68Ga‑PSMA may show reduced sensitivity and quantitative accuracy, partly due to respiratory motion and lower spatial resolution. Device-based motion‑correction methods have limitations. Data‑driven gating (DDG) offers a hardware‑free alternative, though its impact on PSMA PET, especially 68Ga‑PSMA has not been systematically evaluated. To evaluate the quantitative and qualitative performance of the DDG motion-correction method in 68Ga-PSMA and 18F-DCFPyL-PSMA PET/CT, focusing on metastatic lymph node, lung, and bone lesions, and to assess its robustness across tracers.