Arquivos de neuro-psiquiatria
Unexpected coagulopathy in thrombolyzed stroke: experience from a single center in Chile
By Brunser AM, Mansilla E, Gutierrez M and 4 others.
Abstract
Background
The effectiveness of intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) is time-dependent, and waiting for coagulation tests (COT) may delay treatment initiation. In several countries, IVT is initiated without waiting COT results; this approach has not been evaluated in South America. In this region, excessive alcohol consumption may increase the prevalence of unrecognized chronic liver disease.
Objective
To determine the frequency of unsuspected coagulation abnormalities among patients with AIS treated with IVT at a single tertiary care center in Chile.
Methods
A prospective analysis of all patients treated with IVT at Clínica Alemana between June 2016 and July 2025, assessing the proportion of individuals with unexpected coagulation abnormalities.