BMJ open respiratory research
A three-month physiology score correlates with CLAD after lung transplant
By Yang J, Fu A, Belousova N and 7 others.
Abstract
Rationale
Long-term survival after lung transplant is limited by chronic lung allograft dysfunction (CLAD). Oscillometry is a novel pulmonary function technique that complements spirometry. We hypothesise that oscillometry and spirometry at 3 months post-transplant are associated with CLAD.
Methods
Double lung transplant recipients (n=280) were enrolled from 2017 to 2020 for oscillometry at the first post-transplant spirometry. We excluded re-transplantation and patients missing 3-month oscillometry-spirometry data. Patients who died within 3 years where a CLAD diagnosis was ascertained were included. We used Mann-Whitney U and Pearson’s χ2 tests for group comparisons, logistic regression to assess the associations of spirometry and oscillometry with CLAD, and receiver operating characteristic curves to identify the threshold values for CLAD.