Biochemistry and biophysics reports
Mayonnaise intake and depression: dose-response in humans and neurobehavioral and molecular mechanisms in zebrafish
By Yao Z, Dong X, Liu X and 3 others.
Abstract
Background
Depression is the leading global cause of disability, yet dietary research has overlooked condiments as a concentrated, habitual exposure. Emulsified high-fat condiments may drive neuroinflammation independently of total caloric intake, offering a feasible prevention target, but their mental health impact remains unexamined.
Methods
This study comprised two phases: (1) A cross-sectional analysis of 2423 adults from NHANES 2005-2006, examining associations between condiment intake frequency and PHQ-9 scores using negative binomial regression; (2) A zebrafish experiment where adult fish were exposed to 0%, 1%, 5%, or 10% mayonnaise for 4 weeks, followed by behavioral assessment and qPCR analysis of hub genes identified by network toxicology.