Clinical, cosmetic and investigational dermatology
Associations of Total IgE, Eosinophils, and IL-5 with SCORAD-Defined Severity in High-IgE Atopic Dermatitis: A Retrospective Exploratory Study
By Ma W, Liu J, Li R and 1 others.
Abstract
Background
Atopic dermatitis (AD) is characterized by marked immune heterogeneity, and high-IgE AD is commonly associated with Th2-skewed inflammation and greater disease burden. However, the relationships between downstream Th2-related peripheral blood markers and multidimensional disease severity in high-IgE AD remain incompletely understood.
Methods
This single-center retrospective exploratory study included adult patients with AD diagnosed between June 2023 and June 2025. Among 140 eligible patients with complete core data, 92 patients with high-IgE AD, defined as baseline serum total IgE ≥100 IU/mL, were included in the primary analysis. Patients were stratified according to SCORAD scores. Associations of total IgE, eosinophil (EOS) count, and IL-5 with SCORAD, EASI, NRS pruritus score, and DLQI were analyzed.