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Clinical Outcomes of Partial Injection Underwater Endoscopic Mucosal Resection for Superficial Non-ampullary Duodenal Epithelial Tumors (With Video)
By Misawa N, Higurashi T, Asano Y and 8 others.
Abstract
Objectives
Although endoscopic resection is widely performed for superficial non-ampullary duodenal epithelial tumors (SNADETs), conventional endoscopic mucosal resection (CEMR) may be associated with suboptimal complete resection rates. Partial injection underwater EMR (PI-UEMR) has been proposed to improve the visualization of distal lesion margins and facilitate en bloc resection. We aimed to evaluate the outcomes of PI-UEMR for SNADETs, using CEMR as a historical institutional comparator.
Methods
This single-center observational cohort study included patients who underwent endoscopic mucosal resection for SNADETs between September 2015 and December 2025. Lesions treated with CEMR or PI-UEMR were analyzed. The primary outcomes were en bloc and R0 resection rates. The secondary outcomes included histological diagnosis and procedure-related adverse events, including intraoperative perforation, delayed perforation, and delayed bleeding.