Open forum infectious diseases
Characterization of an Unusual Severe Yellow Fever Outbreak in the Colombian Andean Region
By Forero-Delgadillo AJ, Morales-Olivera JA, Narvaez-Ramirez PO and 15 others.
Abstract
Background
Yellow fever (YF) reemerged in Colombia's Andean region during 2024-2025, outside the country's historically recognized endemic areas. We characterized critically ill adults admitted during this outbreak and described clinical features, organ dysfunction, supportive care, and in-hospital outcomes.
Methods
We conducted a prospective observational cohort study of consecutive adults with reverse transcription polymerase chain reaction (RT-PCR)-confirmed YF admitted to the national referral intensive care unit in Ibagué, Tolima, Colombia, from March through September 2025. Clinical, laboratory, complication, intervention, and outcome data were prospectively captured using a standardized case report form.