Frontiers in pediatrics
Copeptin and albumin in children with undernutrition
By Hatipoğlu HU, Güler A and Elevli M.
Abstract
Background
Anthropometric assessment remains the cornerstone of the identification and classification of pediatric undernutrition, whereas the role of laboratory biomarkers is less well established.
Objective
To evaluate serum copeptin in children with undernutrition and to compare its discriminatory performance with that of serum albumin.
Methods
This single-center cross-sectional case-control study included children aged 1 month to 18 years with undernutrition and healthy controls recruited from the same clinical setting. Serum copeptin concentrations were measured by enzyme-linked immunosorbent assay. Receiver operating characteristic analysis and multivariable logistic regression were performed. Age-stratified and sensitivity analyses were also conducted.