Alzheimer's & dementia : the journal of the Alzheimer's Association
Cerebral blood flow as a biomarker of resilience in cognitively unimpaired APOE ɛ4 carriers
By Quiring M, Kapoor A, Alitin JPM and 14 others.
Abstract
Introduction
It remains unclear whether medial temporal lobe (MTL) hyperperfusion in cognitively unimpaired apolipoprotein E (APOE) ɛ4 carriers reflects resilience or dysfunction. We examined whether cortical MTL cerebral blood flow (CBF) relates to cognition differently in APOE ɛ4 carriers and noncarriers with and without AD pathophysiological changes.
Methods
One hundred forty-eight cognitively unimpaired older adults underwent pseudo-continuous arterial spin labeling MRI to quantify MTL CBF and assessment of memory and executive function. In a subset (n = 126), AD pathology was indexed using plasma phosphorylated tau 217 (pTau217).