BMJ
Acetic acid chromoendoscopy for detection of neoplastic Barrett's oesophagus: stepped wedge cluster randomised controlled trial (ACID-trial)
By Beaufort IN, Boer LS, Milne AN and 20 others.
Abstract
Objective
To assess the added value of acetic acid chromoendoscopy (AAC) for the detection of dysplasia and oesophageal adenocarcinoma during Barrett's oesophagus surveillance endoscopies.
Design
Prospective, open label, stepped wedge cluster, randomised trial.
Setting
18 Dutch community hospitals.
Participants
Patients undergoing surveillance for Barrett's oesophagus were eligible, excluding those with known or previously treated dysplasia.
Interventions
Hospitals randomly shifted from surveillance without AAC (control) to AAC (intervention), with endoscopists trained before implementation. Targeted biopsies were obtained if lesions were present; random four quadrant biopsies were conducted.