European respiratory review : an official journal of the European Respiratory Society
The prognostic value of physical functioning on survival in patients with nonsmall cell lung cancer: a systematic review and meta-analysis
By Arents E, Haesevoets S, Van Overbeke M and 11 others.
Abstract
Background
Physical functioning has emerged as a potentially valuable prognostic indicator in patients with nonsmall cell lung cancer (NSCLC). This systematic review and meta-analysis aimed to evaluate the prognostic value of objectively measured components of physical functioning on survival outcomes across treatment modalities.
Methods
Medline, Web of Science and Scopus were searched up to May 2025. Eligible studies included adult patients with NSCLC and assessed at least one objectively measured physical functioning indicator in relation to survival outcomes. Indicators were categorised using the International Classification of Functioning, Disability and Health (ICF) framework into "body functions and structures", "activities" and "participation" and studies were stratified into "surgery" and "nonsurgery" groups. Meta-analyses were conducted when data permitted it.