Journal of applied clinical medical physics
Comparison of two close-packing methods for vertex placement in lattice radiotherapy (LRT)
By Song Y, Ma P and Dai J.
Abstract
Background
Lattice Radiation Therapy (LRT) is characterized by its 3D-mouldated spatial dose distribution of vertices inside the lattice volume with high peak-to-valley dose ratio (PVDR) for enhancing tumor control and reducing normal tissue toxicity. While face-centered cubic (FCC) and hexagonal close-packed (HCP), both achieving maximum spatial packing density, have been used for vertex placement, a direct comparative analysis of their dosimetric performance is lacking.
Purpose
This study aimed to systematically compare FCC and HCP methods for vertex placement under identical conditions to determine which yields superior dosimetric outcomes, specifically regarding the peak-to-valley dose ratio (PVDR), and to provide data supporting the standardization of LRT planning.