Medical physics
Segment anything model (SAM)-driven prompt-guided interactive delineation of gross tumor volume for rectal cancer neoadjuvant radiotherapy
By Wu S, Geng J, Bai L and 4 others.
Abstract
Background
Segment Anything Model (SAM), a prompt-guided foundation model, exhibits substantial potential for medical image segmentation by incorporating prior knowledge through user-defined prompts. However, the application of SAM in radiotherapy target delineation remains limited.
Purpose
This study proposes a feasible prompt-guided interactive delineation workflow driven by an optimized SAM.
Methods
A total of 100 rectal cancer neoadjuvant radiotherapy cases were collected (60 for training and 40 for testing). This study utilized bounding-box prompts to guide SAM for GTV segmentation. Physicians manually draw box prompts on certain slices, while box prompts for the remaining slices are automatically generated using an interpolation strategy. Four fine-tuning strategies for SAM training were evaluated, and the impact of prompt numbers and placements was assessed as well. The performance of the finalized workflow with optimized SAM was compared with five state-of-the-art (SOTA) models, and its robustness to prompt variations in middle-slice selection and box-prompt margins was analyzed.