PloS one
The association of cardiovascular comorbidities with malignant and benign colorectal neoplasms
By Wani F, Marrufo IM, Bhavsar V and 3 others.
Abstract
Background
Each year, thousands of patients are diagnosed with gastrointestinal (GI) bleeding. Many of these patients undergo colonoscopy and are subsequently diagnosed with benign or malignant colorectal neoplasms. The aim of this study is to evaluate whether patients with cardiovascular comorbidities, many of whom are on anti-platelet or anticoagulation therapy, are more likely to be diagnosed with new benign or malignant colorectal neoplasms than patients without cardiovascular comorbidities.
Methods
From the 2007-2011 NIS, 802,080 primary lower GI bleed admissions (ICD-9) were identified; 283,925 had cardiovascular comorbidities. We compared patients with vs without these comorbidities for the primary outcome of new benign or malignant colorectal neoplasms. Weighted analyses accounting for the complex survey design were performed in SAS 9.4, with trends assessed using Cochran-Armitage tests and linear regression and associations with colorectal cancer stage evaluated by multinomial logistic regression (p ≤ 0.05).