PloS one
The global burden of female breast cancer attributable to high fasting plasma glucose: A comprehensive analysis of the GBD database from 1990 to 2023
By Shi H, Song Z, Chen Y and 2 others.
Abstract
Background
High fasting plasma glucose (HFPG) is an established risk factor for breast cancer (BC). However, accurate and up-to-date estimates of the global burden of breast cancer attributable to high fasting plasma glucose (BC-HFPG) are scarce. This study aims to provide a comprehensive analysis of the burden of BC-HFPG using data from the Global Burden of Disease (GBD) database from 1990 to2023.
Methods
We performed a comprehensive descriptive analysis of the burden of female BC-HFPG based on the GBD 2023 database. The core metrics analyzed were the absolute number of death and disability-adjusted life years (DALY). To ensure comparability across populations with differing age structures, we also analyzed the age-standardized mortality rate (ASMR) and the age-standardized DALY rate (ASDR). The average annual percent change (AAPC) was used to further comprehensively describe the burden of disease and its changing trends. In addition to the retrospective analysis from 1990 to 2023, we used the Bayesian age-period-cohort (BAPC) model to generate predicted data on the burden of female BC-HFPG from 2024 to 2050.