CNS neuroscience & therapeutics
Cerebral Artery Stenosis, Glymphatic Dysfunction, and Cognitive Trajectories: A Longitudinal Cohort Study of Community-Dwelling Older Adults
By Yuan W, Niu X, Lan L and 1 others.
Abstract
Aims
We aimed to investigate the role of glymphatic dysfunction in the association between stenosis and cognition.
Methods
Older adults from a longitudinal cohort underwent magnetic resonance angiography to quantify cerebral artery stenosis burden. Glymphatic function was evaluated using diffusion tensor imaging-analysis along the perivascular space (DTI-ALPS) and free water in white matter (FW-WM). Global cognitive performance was assessed using the Mini-Mental State Examination (MMSE) and the Clinical Dementia Rating-Sum of Boxes (CDR-SB). Mediation analyses examined indirect effects, and longitudinal cognitive outcomes were analyzed using linear mixed-effects and Cox proportional hazards models.