Drug design, development and therapy
Effect of Etomidate Induction on Intraoperative Hemodynamics, Postoperative Inflammation, and Recovery After Laparoscopic Sleeve Gastrectomy: A Retrospective Cohort Study
By Qi J, Zheng Z, Gu Y and 3 others.
Abstract
Background
Etomidate is commonly used for anesthetic induction because of its favorable hemodynamic profile but may cause adrenocortical suppression. Whether its use is associated with hemodynamic stability, and postoperative inflammatory and recovery outcomes after laparoscopic sleeve gastrectomy (LSG) remains uncertain.
Methods
This single-center retrospective cohort study included adults undergoing elective LSG from January 2014 through December 2024. The exposure was etomidate use during anesthetic induction. The primary outcome was time-weighted average MAP (TWA-MAP). Secondary outcomes included time-weighted average MAP below 65 mmHg (TWA65), hypotensive event rate, proportion of time with hypotension, generalized average real variability of MAP (ARV-MAP), postoperative C-reactive protein (CRP) and interleukin-6 (IL-6), and recovery outcomes. Propensity score-based inverse probability of treatment weighting (IPTW) adjusted for measured baseline confounding; sensitivity analyses assessed the robustness of the findings.