Clinical interventions in aging
Preoperative Frailty and Risk of Post-ERCP Pancreatitis in Older Adults with Choledocholithiasis
By Zhang F, Zeng M, Wan Y and 4 others.
Abstract
Background
Frailty is increasingly considered when evaluating surgical risk in older adults. However, evidence regarding whether frailty contributes to the risk of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis in elderly patients is limited.
Objective
We aimed to evaluate whether preoperative frailty was associated with the development of post-ERCP pancreatitis (PEP) in elderly patients undergoing ERCP.
Methods
Patients aged 65 years or older who underwent ERCP for choledocholithiasis were retrospectively included. Frailty was assessed preoperatively using an electronic health record-based composite frailty index (EHR-CFI). PEP was defined according to the Cotton consensus criteria. Multivariable logistic regression, receiver operating characteristic (ROC) analysis, and net reclassification improvement (NRI) were used to explore the incremental contribution of frailty to PEP risk stratification.