Drug design, development and therapy
Comparative Analysis of Progestin Intervention for Non-Atypical Endometrial Hyperplasia in Infertile Females with Anovulation: A Retrospective Study
By Zhang X, Xu Z, Wang Y and 4 others.
Abstract
Objective
To compare the efficacy of progestin intervention for non-atypical endometrial hyperplasia (non-atypical EH) in infertile patients with ovulatory dysfunction, and to explore factors associated with histological regression.
Methods
A retrospective cohort study was conducted at a tertiary reproductive medicine center. A total of 171 infertile females with anovulation diagnosed with non-atypical EH by hysteroscopic biopsy between March 2021 and August 2024 were enrolled. Patients were divided into polycystic ovary syndrome (PCOS) group (n=89) and diminished ovarian reserve (DOR) group (n=82) according to ovarian reserve function. All patients received 3-month oral progestin therapy. The study aims to analyze and compare the regression of endometrial hyperplasia after 3 months of treatment. Multivariate logistic regression was used to analyze independent factors affecting treatment response.