The Lancet. Public health
Outcomes of Mindful Mood Balance for Moms, online mindfulness-based cognitive therapy for perinatal depressive relapse prevention in the USA: a two-arm, single-blind, pragmatic randomised clinical trial
By Dimidjian S, Gallop R, Goodman SH and 14 others.
Abstract
Background
Effective and accessible approaches to prevent depressive relapse and reduce symptoms are crucial for addressing the major public health problem of depression among perinatal women. We aimed to evaluate the effectiveness of Mindful Mood Balance (MMB) for Moms plus usual care (hereafter MMB for Moms)-a web-based mindfulness-based cognitive therapy programme customised for perinatal women-compared with usual care only, in reducing depressive relapse and symptoms.
Methods
This single-blind, randomised clinical trial was done across the USA, in euthymic pregnant women with recurrent depression who were on recent or current antidepressant medication. Recruitment occurred from March 7, 2019, to July 8, 2020 (data collection was completed Sept 12, 2021). Participants were randomly assigned to MMB for Moms, or usual care. Primary outcomes were reduction in depressive relapse risk and symptom burden, assessed using the Mini International Neuropsychiatric Interview and Patient Health Questionaire-9, respectively, across the study period. Outcomes were assessed from baseline until 6-months postpartum in three phases (intervention, end of intervention to delivery, and postpartum). The trial was registered with ClinicalTrials.gov, NCT03623620, and is complete.