CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
Factors associated with early death from de novo metastatic breast cancer in Ontario, Canada
By Thomas P, Carter B, Earle CC and 9 others.
Abstract
Background
Early death from female breast cancer is influenced by disease biology and factors such as age, marginalization, socioeconomic status, rurality, and access to primary care. Our objective was to investigate factors associated with early death in the subgroup of patients diagnosed with advanced de novo metastatic breast cancer, defined by the presence of distant metastatic disease at initial presentation.
Methods
We used linked health care administrative data from Ontario, Canada, from 2010 to 2019 to conduct a population-based retrospective cohort study. We identified adults diagnosed with de novo metastatic breast cancer through the Ontario Cancer Registry. The primary outcome was the frequency of early death, defined as death within 6 months of cancer diagnosis. We used a multivariable logistic regression model to determine the patient, cancer, and provider characteristics associated with early death.