Canadian respiratory journal
Serum Glycoprotein VI in Acute Pulmonary Embolism: Association With Radiological Thrombus Burden and Clinical Risk Indicators
By İnan MM, Sayhan MB, Salt Ö and 3 others.
Abstract
Background
Pulmonary embolism (PE) is a life-threatening condition requiring rapid diagnosis and accurate risk stratification. Biomarkers reflecting thromboinflammatory processes may improve early clinical assessment. Glycoprotein VI (GPVI), a key receptor involved in platelet activation, has been implicated in thrombus formation; however, its clinical relevance in PE remains unclear.
Objective
To examine the association of serum GPVI with radiological thrombus burden and clinical risk indicators in acute PE, while retaining the original PE-versus-control comparison only as a secondary exploratory case-control discrimination analysis, not as a diagnostic-accuracy analysis.
Methods
In this cross-sectional study, the analytic cohort comprised 50 patients with CTPA-confirmed acute PE and 25 control participants. Serum soluble GPVI (sGPVI) was measured by a colorimetric sandwich ELISA. The study-recorded CTPA thrombus-burden categories were analyzed as lower, intermediate, and higher radiological burden and separately from an exploratory ESC-aligned risk reconstruction. For ICU admission, parsimonious multivariable and incremental analyses evaluated GPVI beyond PESI with internal validation. A PE-versus-control ROC comparison with D-dimer was retained only as a secondary exploratory case-control discrimination analysis and was not treated as an estimate of diagnostic accuracy.