Frontiers in dental medicine
Comparative evaluation of the effect of simvastatin and modified triple antibiotic paste on microhardness and fracture resistance of root dentin-an in vitro study
By Kumar P, Sreekumar M, Shetty SV and 3 others.
Abstract
Background
An ideal intracanal medicament should provide effective antimicrobial action while preserving radicular dentin. This in vitro study compared the effects of simvastatin and modified triple antibiotic paste (mTAP) on root dentin microhardness and fracture resistance.
Materials and methods
Fifty-four single-rooted human premolars were randomly assigned to three groups (n = 18): simvastatin, mTAP, and control. Following root canal preparation, medicaments were placed for 1 week. Dentin microhardness was measured using a Vickers hardness tester, and fracture resistance was assessed with a universal testing machine. Statistical significance was set at p < 0.05.