Psychiatric morbidity is associated with cognitive impairment, whereas diagnostic category may shape its profile: a transdiagnostic study of inflammation, salivary biomarkers, and health-related quality of life

Background

Cognitive impairment is highly prevalent across psychiatric disorders, but it remains unclear how psychiatric morbidity and diagnostic category contribute to its presence and profile and whether inflammation and salivary synaptic proteins are associated with cognitive impairment across diagnoses. This transdiagnostic study integrated clinical, cognitive, inflammatory, and salivary biomarker data to examine these questions.