United European gastroenterology journal
Symptom Profiles Compatible With Disorders of Gut-Brain Interaction in Individuals With Coeliac Disease on a Long-Term Gluten-Free Diet
By van Gils T, Törnblom H, van Overveld F and 7 others.
Abstract
Background
Persistent gastrointestinal (GI) symptoms are frequently reported in patients with coeliac disease (CD). Knowledge about the role of disorders of gut-brain interaction (DGBI) as the cause of these persistent symptoms remains limited.
Objective
To assess the prevalence and factors associated with DGBI-compatible symptom profiles in individuals with CD on a long-term gluten-free diet (GFD).
Methods
Adult members of the Dutch Coeliac Society completed an online survey, including the Rome IV diagnostic questionnaire and validated questionnaires assessing psychological distress, non-GI somatic symptom severity, and health-related quality of life (QOL). Only individuals with CD adhering to a GFD ≥ 1 year were included. A population-based Dutch cohort served as the reference group.