Diabetes/metabolism research and reviews
Real-World Databases in Diabetes: A Systematic Review
By Thomas JJC, Meffen A, Rizzi A and 13 others.
Abstract
Aim
To identify publications that describe RWD databases in the field of diabetes and map their key characteristics.
Methods
Databases were searched (MEDLINE, SCOPUS, CINAHL from January 2018 to October 2025) to identify relevant publications describing RWD databases. Eligible studies were identified as RWD databases that contained more than 1000 adults and were followed up for one year or longer. Metadata including population, sample size, and outcomes were then extracted.
Results
A total of 610 eligible RWD databases were identified from 1779 included articles. Databases were identified in 74 countries, with the majority collected in Europe (n = 193). Only 22 databases were identified in lower- and- middle income countries (as defined by the World Bank). Demographics, prescription, diagnosis, and biochemical information were collected frequently; however, mortality and technology related variables (CGM usage) were found in fewer datasets. Very few databases were open access however 205 mentioned having the possibility for data sharing.