PloS one
Circulating microRNAs as potential candidate biomarkers of left ventricular reverse remodeling after myocardial infarction: A pilot study
By Gozdowska R, Konopka M, Hojka-Osińska A and 6 others.
Abstract
Background
Myocardial infarction (MI) induces cardiac remodeling and lead to heart failure. Some patients experience reverse remodeling, characterized by improved LV function. MicroRNAs (miRNAs) regulate gene expression and play a crucial role in remodeling processes.
Objectives
We aimed to investigate the role of miRNAs in cardiac reverse remodeling after MI and identify candidate miRNAs that could predict better response to cardiac rehabilitation.
Methods
The study enrolled 39 patients following their first MI. For final analysis, 10 patients meeting echocardiographic criteria for LVRR at 8-week follow-up (absolute LVEF increase ≥ 10% or LVESV reduction ≥ 15%) were matched with 10 patients with stable LV status (SLVS). All patients completed a cardiac rehabilitation program. Expression of 375 circulating miRNAs was quantified - those with higher baseline accumulation in the LVRR group were identified as candidate biomarkers and their target genes were analyzed.