Zhonghua wei zhong bing ji jiu yi xue
Application of a spontaneous breathing trial based on high-flow oxygen therapy in weaning of mechanically ventilated patients
By Zhang L, Deng M, Li H and 8 others.
Abstract
Objective
To evaluate the application efficacy of a spontaneous breathing trial (SBT) based on high-flow oxygen therapy (HFOT) during the weaning process in mechanically ventilated patients.
Methods
A randomized controlled trial was conducted. A total of 163 patients undergoing invasive mechanical ventilation admitted to the Department of Critical Care Medicine, Zhongda Hospital, Southeast University, from September 2024 to July 2025 were enrolled and randomly assigned to the HFOT group (80 cases) or the pressure support ventilation (PSV) group (83 cases). The HFOT group received SBT based on HFOT, while the PSV group received SBT based on PSV. Baseline data were collected and compared between the two groups, and adverse events during SBT were recorded. The primary outcome was the success rate of extubation within 48 hours. Secondary outcomes included vital signs, sputum grade, arterial blood gas parameters measured before SBT and 30 minutes after SBT initiation, SBT success rate, and prognostic outcomes [duration of mechanical ventilation, length of intensive care unit (ICU) stay, hospitalization costs, ICU mortality, in-hospital mortality, and 28-day mortality].