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Long-term oncological outcomes after nipple-sparing mastectomy and implant-based immediate breast reconstruction in a population-based cohort of breast cancer patients
By Sackey H, Oikonomou I, Liu Y and 6 others.
Abstract
Background
Nipple-sparing mastectomy (NSM) offers superior cosmetic and patient-reported outcomes compared with skin-sparing mastectomy (SSM), although its oncological safety remains debated. This study evaluated recurrence and survival after NSM versus SSM in women with breast cancer receiving implant-based immediate breast reconstruction (IBR).
Methods
The population-based Stockholm Breast Reconstruction Database, including all women with breast cancer who underwent implant-based IBR in Stockholm from 2005 to 2015, was reviewed. Data were collected from medical chart review and the National Quality Register for Breast Cancer. The primary outcomes were long-term local recurrence (LR) rates and overall survival (OS) after NSM versus SSM. Survival probabilities and hazard ratios (HR) with their 95% confidence interval (c.i.) were estimated with a maximum 12 years of follow-up.