Helicobacter
Intermediate OLGA/OLGIM Stages as Early Risk Markers for Gastric Cancer: A Systematic Review and Meta-Analysis
By Frías-Ordóñez JS, Niño-Ramírez S, Pérez JC and 7 others.
Abstract
Background
The Operative Link on Gastritis Assessment (OLGA) and Operative Link on Gastric Intestinal Metaplasia Assessment (OLGIM) systems stratify gastric cancer (GC) risk according to the extent of gastric atrophy and intestinal metaplasia. However, the clinical significance of intermediate stages remains uncertain.
Objective
To evaluate the association between OLGA/OLGIM stages and GC, with particular focus on the potential role of intermediate stages as early histological risk markers.
Methods
A systematic review and meta-analysis (PROSPERO CRD42024549931) was conducted according to PRISMA 2020 guidelines. Cohort, case-control, and cross-sectional studies reporting GC incidence or prevalence according to OLGA and/or OLGIM stage were included. Methodological quality was assessed using the Newcastle-Ottawa Scale and certainty of evidence using GRADE. Random-effects models were used to calculate pooled odds ratios (OR) and risk ratios (RR).