Annals of intensive care
Early piperacillin exposure during continuous infusion in critically ill patients: the impact of renal and liver dysfunctions
By Conseil M, Lakbar I, Laurino A and 10 others.
Abstract
Objective
To assess early piperacillin exposure in critically ill patients receiving continuous infusion piperacillin-tazobactam, identify clinical determinants of underexposure and overexposure, and evaluate piperacillin concentrations across organ dysfunction phenotypes.
Design
Retrospective, single-center observational study.
Setting
A 20-bed medical-surgical intensive care unit of a university hospital.
Patients
All consecutive adult critically ill patients receiving continuous-infusion piperacillin-tazobactam with at least one total plasma piperacillin concentration measurement.