Exercise modality and planned weekly exercise exposure for motor outcomes in Parkinson's disease: a systematic review, Bayesian network meta-analysis, and meta-regression

Exercise modality and planned weekly structured-exercise exposure may provide complementary information for Parkinson's disease motor outcomes, but their outcome-specific effects and evidential confidence remain uncertain.

We synthesized 173 randomized trials using covariance-aware Bayesian random-effects network meta-analysis for motor symptoms, balance, walking speed, and Timed Up and Go (TUG). A key secondary analysis estimated exercise-class-adjusted associations per 250 metabolic equivalent task minutes/week, with pre-specified sensitivity analyses.