Brain and behavior
Comparative Effectiveness of Intravenous Tenecteplase versus Alteplase in Posterior Circulation Ischemic Stroke: A Systematic Review and Meta-Analysis
By Shafiq SB, Uddin A, Hussain M and 9 others.
Abstract
Background
Posterior circulation ischemic stroke (PCIS) is associated with substantial morbidity and mortality, and the optimal intravenous thrombolytic strategy in this subgroup remains unclear.
Methods
We searched databases for studies comparing intravenous tenecteplase with alteplase in adults with PCIS. The primary outcome was functional independence at 90 days (mRS 0-2). Secondary outcomes included other functional outcomes, reperfusion, hemorrhagic complications, and mortality.