Photodermatology, photoimmunology & photomedicine
Daylight Photodynamic Therapy Alone or Combined With Transepidermal Drug Delivery Techniques for Skin Field Cancerization: An Immunohistochemical Study of Epidermal Carcinogenesis and Dermal Remodeling Markers
By Bento CO, Pantaleão L, Filho PJS and 3 others.
Abstract
Background
Daylight photodynamic therapy (DL-PDT) has been combined with transepidermal drug delivery (TED) techniques to enhance photosensitizer penetration. Although studies have suggested improved clinical and histological outcomes with DL-PDT combined with ablative laser, evidence regarding carcinogenesis and dermal remodeling markers remains limited.
Objective
To evaluate changes in epidermal carcinogenesis and dermal remodeling markers after standard DL-PDT compared with DL-PDT combined with TED techniques for facial field cancerization.