Revista da Associacao Medica Brasileira
Retrospective study of inflammatory markers in high-grade cervical lesions
By Yıldız P, Topçu G, Aydın G and 1 others.
Abstract
Objective
The aim of this study was to evaluate the predictive value of systemic inflammation markers for abnormal cervical screening results and high-grade cervical lesions in women participating in a human papillomavirus- and cytology-based screening program, thereby determining colposcopy indications more accurately to reduce unnecessary colposcopy requests and prevent overtreatment.
Methods
A total of 2,758 women who underwent cervical cancer screening between 2020 and 2025 were included in this retrospective cross-sectional study. Abnormal screening results were defined as abnormal cytology (≥Atypical squamous cells of undetermined significance [ASC-US]) and/or high-risk human papillomavirus positivity. Hematological parameters measured within 1 month prior to screening were used to calculate neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammation index. Continuous variables were evaluated using nonparametric tests, and the independent predictors of abnormal screening results and high-grade lesions were identified using logistic regression models.