Pathological fracture as initial manifestation of malignancy and survival based on diagnoses: a register-based cohort study from the Swedish Fracture Register and the Swedish Cancer Register

Background and purpose: Pathological fracture as the initial manifestation of malignancy is a clinical challenge requiring rapid treatment despite limited prognostic information. We aimed to describe definitive diagnoses and survival in patients presenting with a pathological fracture as initial manifestation of malignancy.

Methods

We performed a nationwide register-based cohort study using the Swedish Fracture Register (SFR) and Swedish Cancer Register (SCR), 2014-2023. We included patients with a pathological fracture classified as unknown in the SFR at treatment. Survival was analyzed using Kaplan-Meier and Cox regression.