Clinical cardiology
Prognostic Significance and Factors Associated With Worsening LV Dilatation in Heart Failure
By Averbuch T, Miller RJH, Ezekowitz J and 4 others.
Abstract
Background
Left-ventricular end-systolic dimension (LVESD) and end-diastolic dimension (LVEDD) are associated with adverse outcomes in heart failure (HF). The prognostic significance of a change in LVESD or LVEDD is uncertain.
Methods
This retrospective cohort study included patients experiencing ≥ 1 HF hospitalization or emergency department (ED) visit between April 2008 and March 2016 and underwent ≥ 2 echocardiograms, separated by ≥ 6 months. The primary outcome was the composite all-cause mortality, HF hospitalization, and ED visits for HF. We performed cut-point analysis to determine the threshold increase in LVESD or LVEDD associated with all-cause mortality. We evaluated characteristics associated with an increase in LVESD and LVEDD above threshold using multivariable logistic regression.