Pain research & management
Prevalence and Clinical Phenotypes of Headache in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: The MOGHEAD Study
By Bianco A, Lucchini M, Sottani C and 8 others.
Abstract
Background
Headache associated with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is poorly characterized.
Objective
To investigate the prevalence, clinical phenotypes, and longitudinal evolution of headache in MOGAD.
Methods
In this single-center retrospective cohort study based on prospectively collected clinical data, consecutive adult patients diagnosed with MOGAD between 2020 and 2024 were enrolled. Demographic, clinical, and radiological data were collected. Headaches were classified according to the International Classification of Headache Disorders. Patients underwent quarterly evaluations over 1 year. Pain severity was assessed using the Numeric Rating Scale at baseline and at the 1-year visit, while headache-related disability was assessed using the Migraine Disability Assessment at the 1-year visit in patients reporting headache.