Arquivos de neuro-psiquiatria
Parkinson's disease-associated psychosis in a Brazilian sample: prevalence and clinical profile
By Dourado HN, Oliveira IJW, Lobo CC and 3 others.
Abstract
Background
Psychosis is a frequent and disabling non-motor complication of Parkinson's disease (PD). Reported prevalence varies widely, and data in Brazilian cohorts remain scarce.
Objective
To estimate the prevalence of PD-associated psychosis (PDP) in a Brazilian cohort and to describe its sociodemographic and clinical profile.
Methods
We conducted a cross-sectional study in a Brazilian movement disorders outpatient clinic between May and December of 2022. Adult patients with idiopathic PD defined by the United Kingdom's Parkinson's Disease Society Brain Bank criteria were consecutively evaluated. Sociodemographic and clinical variables were collected. Psychosis was assessed using the diagnosis criteria proposed by the National Institute of Neurological Disorders and Stroke and the National Institute of Mental Health (NINDS/NIMH) and graded with the Movement Disorders Society's Unified PD Rating Scale (MDS-UPDRS). Cognitive screening was performed using the Mini-Mental State Examination (MMSE), and disease severity was assessed with the modified Hoehn & Yahr scale (mH&Y). Neuropsychiatric symptoms were evaluated with the Neuropsychiatric Inventory Questionnaire (NPI-Q). Descriptive analyses and exploratory univariate comparisons were performed.