Molecular imaging and radionuclide therapy
Prognostic Value of Primary Tumor and Immune Organ Metabolic Parameters Derived from Pretreatment 18F-FDG PET/CT in Gastric Adenocarcinoma: A Retrospective Survival Analysis
By Özçevik H, Öner Tamam M and Acar Tayyar MN.
Abstract
Objective
To investigate the association of primary tumor volume-based parameters and immune organ (liver, spleen, bone marrow) metabolic parameters and their derived ratios [spleen-to-liver ratio (SLR), bone marrow-to-liver ratio (BLR), spleen-to-bone marrow ratio (SBR)], measured on pretreatment 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), with overall survival in gastric adenocarcinoma.
Methods
127 patients with histopathologically confirmed gastric adenocarcinoma who underwent pretreatment 18F-FDG PET/CT were retrospectively evaluated. Maximum standardized uptake value, mean standardized uptake value, metabolic tumor volume, total lesion glycolysis (TLG) and immune-organ SUVs were measured and the ratios calculated. Survival analyses used the Kaplan-Meier method, log-rank test, and Cox regression.