The Journal of the Egyptian Public Health Association
Impact of lipid accumulation product on cardiometabolic multimorbidity and the mediating effect of leukocytes: evidence from a prospective cohort study among middle-aged and elderly chinese adults
By Maiturouze A, Li Y and Li D.
Abstract
Background
Cardiometabolic multimorbidity (CMM) is a growing public-health burden in ageing populations, yet conventional adiposity measures such as body mass index and waist circumference do not adequately capture the visceral fat and lipid-metabolic disturbances that underlie it. We investigated the association between the lipid accumulation product (LAP) and incident CMM in middle-aged and older Chinese adults, and examined whether systemic inflammation mediates this association.
Methods
We analysed data from five waves (2011-2020) of the China Health and Retirement Longitudinal Study (CHARLS), comprising 7563 participants aged 45 years or older who were free of heart disease, stroke, and diabetes at baseline and had complete LAP and white blood cell (WBC) count data. CMM was defined as the coexistence of two or more cardiometabolic conditions among heart disease, stroke, and diabetes. The association between LAP and incident CMM was assessed using Cox proportional-hazards models with subgroup and restricted cubic spline analyses, and the mediating effects of inflammatory markers (WBC count and C-reactive protein [CRP]) were evaluated by causal mediation analysis.