MASCC oncodermatology clinical practice statement: prevention of acute radiation dermatitis using barrier-forming topical agents

MASCC Clinical Practice Statements (CPS) are practice-oriented resources designed to support clinicians by addressing areas of clinical need where high-quality evidence is limited. They reflect expert consensus on current practices, treatment approaches, and modalities commonly used in oncology care. This CPS aims to provide practical guidance for the prevention of acute radiation dermatitis (ARD) using barrier-forming topical agents.

This CPS was developed based on a comprehensive review of the literature identified through MEDLINE, EMBASE, and Cochrane CENTRAL conducted up to April 23, 2026, followed by structured discussions among experts from the MASCC Oncodermatology Study Group. The findings were synthesized into bullet points to provide a practical guide to optimal standard-of-care practices.