Journal of transplantation
Thoracoabdominal Normothermic Regional Perfusion Attenuates the Protective Effect of Hypothermic Machine Perfusion on Delayed Graft Function in DCD Kidney Transplantation
By Asassfeh A, Kimura J, Luma E and 5 others.
Abstract
Background
Thoracoabdominal normothermic regional perfusion (TA-NRP) and hypothermic machine perfusion (HMP) reduce ischemia-reperfusion injury after donation after circulatory death (DCD) kidney transplantation, but their combined effects remain unclear.
Methods
Adult DCD kidney-only recipients undergoing pretransplant dialysis in the OPTN registry (2020-2025) were stratified by TA-NRP and HMP. The primary outcome was delayed graft function (DGF). Multivariable logistic regression included a TA-NRP × HMP interaction and adjusted for recipient and donor factors. Death-censored graft survival (DCGS) was evaluated by Kaplan-Meier analysis.