Frontiers in cellular and infection microbiology
Clinical significance of Chlamydia trachomatis and HPV coinfection across cervical lesion severity: a 10-year retrospective study in Southern China
By Li H, Zhao H, Liang L and 2 others.
Abstract
Background
Persistent high-risk HPV infection is the major cause of cervical carcinogenesis, but the clinical relevance of Chlamydia trachomatis (CT) coinfection remains uncertain. We examined the epidemiological patterns of CT-HPV coinfection and their associations with cervical lesion severity among women in Southern China.
Methods
This retrospective study included 21,275 outpatients who underwent concurrent HPV genotyping, CT PCR testing, and cytological or histopathological evaluation between 2015 and 2024. Age-specific patterns and temporal trends were assessed. Age-adjusted logistic regression was used to examine associations of HPV and CT with cervical lesion categories. Six DNA methylation markers were analyzed in a subset of samples.